Imaging of Monoamine Neurotransmitters with Fluorescent Nanoscale Sensors
نویسندگان
چکیده
منابع مشابه
Development of pH-responsive fluorescent false neurotransmitters.
We introduce pH-responsive fluorescent false neurotransmitters (pH-responsive FFNs) as novel probes that act as vesicular monoamine transporter (VMAT) substrates and ratiometric fluorescent pH sensors. The development of these agents was achieved by systematic molecular design that integrated several structural elements, including the aminoethyl group (VMAT recognition), halogenated hydroxy-cou...
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The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogenic amines. Using the Flp-in system, we expressed human PMAT (hPMAT) and human OCT3 (hOCT3) at similar levels in human embryonic kidney 293 cells. Parallel and detailed kinetics analysis revealed distin...
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Background Neurotrophin-3 (NT-3), a member of the neurotrophin family of neurotrophic factors, displays profound neuromodulatory functions in the normal and in the diseased brain. Under physiological conditions, NT-3 is produced by neuronal cells and also by local glial cells. We focused our investigation on the ability of astrocytes to synthesize NT-3 and, additionally, on the active involveme...
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ژورنال
عنوان ژورنال: ChemPlusChem
سال: 2020
ISSN: 2192-6506,2192-6506
DOI: 10.1002/cplu.202000248